ʻO ka Exemestane / Aromasin Cancer Treatment Anti Estrogen Steroids no ka ʻoki ʻana / Bulking Cycle
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Exemestane
Alias: Aromasin;Exemestan
ʻAno: Keʻokeʻo a ʻaneʻane keʻokeʻo Crystalline Powder
ʻIke huahana: ≥ 99%CAS:107868-30-4
Huina mole: C20H24O2
Kaumaha Molekala:296.40
Hoʻohana: hoʻohana ʻia i ka mālama ʻana i ka maʻi maʻi umauma metastatic.a hoʻohana ʻia ma ke ʻano he kōkua i ka mālama ʻana i ka maʻi maʻi umauma mua.
Lohe paha ʻoe i kapa ʻia ʻo Aromasin, ʻo ia kona inoa inoa kaulana loa.Aia kekahi mau hōʻailona ʻē aʻe o ka exemestane, aia nā mea āpau i ka nui like o ka lāʻau lapaʻau.
Nā Manaʻo Manaʻo
ʻO ka maʻi maʻamau o nā mākua no ka maʻi maʻi umauma:
25 mg i hoʻokahi manawa i ka lā
Manaʻo:
- Pono e lawelawe ʻia kēia lāʻau ma hope o ka ʻai ʻana.
Hoʻohana:
- Hoʻoponopono kōkua i nā wahine postmenopausal me ka estrogen-receptor maikaʻi i ka maʻi maʻi umauma mua i loaʻa i ʻelua a ʻekolu mau makahiki o ka tamoxifen a ua hoʻololi ʻia i exemestane no ka hoʻopau ʻana i ka huina o ʻelima mau makahiki o ka hoʻokele hormonal adjuvant.
- Lapaʻau ʻana i ka maʻi maʻi umauma holomua i nā wahine postmenopausal i holomua ka maʻi ma hope o ka lāʻau tamoxifen.
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ʻO Aromasin (Exemestane acetate) kekahi o kēlā mau pūhui ʻē aʻe ʻaʻohe mea i ʻike maoli i ka mea e hana ai.ʻO ia ke kolu o ka hanauna Aromatase Inhibitor (AI) e like me Arimidex (Anastrozole) a me Femera (Letrozole).
ʻO ke kolu o ka hanauna aromatase inhibitors, hoʻohana ʻia i ka mālama ʻana i ka maʻi maʻi umauma metastatic a hoʻohana ʻia i mea kōkua i ka mālama ʻana i ka maʻi maʻi umauma mua.
● ʻO Aromasin kekahi o nā pūhui hoʻopaʻa estrogen ikaika loa.
● ʻO Aromasin kekahi o nā pūhui maikaʻi loa e hoʻohaʻahaʻa i ka hopena aromatizing o nā steroid.
● Loaʻa ka Aromasin no nā mea kūkulu kino e lawe ana i nā steroid anabolic.
● ʻIke ʻia ʻo Aromasin ʻo Exemestane.
● Hana ia ma ka pale ʻana i ka enzyme aromatase, a laila pale i ka hana ʻana o ka estrogen.
● ʻO Aromasin kekahi ʻano .antineoplastic (hormonal) maka.
Hoʻohana ʻia ʻo Aromasin e hakakā i ka maʻi maʻi umauma a hoʻonui i ka testosterone i ke kino.
Hoʻopili ʻo Exemestane i ke kaʻina hana o ka aromatisation.No laila hoʻohaʻahaʻa i ka nui o ka estrogen i loko o ke kino.I ka maʻi maʻi maʻi mua, hiki i ka lawe ʻana i ka exemestane ke kōkua i ka hoʻōki ʻana i ka maʻi maʻi umauma e hoʻi mai.I ka ma'i 'a'ai ma'i ma'i 'a'ai 'o ka ma'i 'a'ai ma'i 'a'ole hiki ke ho'ōki loa i ka ulu 'ana.
ʻO ka Exemestane kahi mea hoʻokae aromatase.ʻO ke ʻano o ia mea e poloka ai i ka enzyme aromatase (loaʻa i loko o ka ʻiʻo o ke kino, ka ʻili, ka umauma a me ka momona), ka mea i hoʻohana ʻia e hoʻololi i nā androgens (nā hormones i hana ʻia e ka adrenal glands) i estrogen.I ka loaʻa ʻole o ka estrogen, e emi ana nā maʻi koko e pili ana i kēia hormone no ka ulu ʻana
ʻO nā pono o Exemestane
>>.Hoʻoulu kino
ʻO Steroidal Exemestane inhibitor e hana ma ka hoʻemi ʻana i ka nui o ka estrogen i hana ʻia e ke kino.Hana ia ma ka kaupalena ʻana i ka hoʻololi ʻana o Testosterone i estrogen a ʻo ka awelika o ka hoʻopau ʻana o ka estrogen he 85%.Hoʻemi ka lāʻau lapaʻau i nā pae estradiol ma kahi o 50%, a me ka hoʻonui nui ʻana i nā pae testosterone.
Exemestane inhibitor e hana ana ma ke kāohi ʻana i ka synthesis o ka estrogen.He kūpono i ka hoʻonui ʻana i nā pae Testosterone a me IGF i ke kino.He mea maikaʻi loa ka lāʻau lapaʻau i ka wā e hoʻāʻo ai kekahi e hoʻihoʻi i nā pae Testosterone kūlohelohe e pale aku ai i kahi pōʻai hope.
>>.Laau anti-estrogen
ʻIke ʻia ʻo ia kekahi o nā lāʻau lapaʻau nui loa, ʻo Exemestane kekahi o nā lāʻau anti-estrogen palekana i hoʻohana nui ʻia e nā mea pāʻani a me nā bodybuilders.ʻO ka lāʻau lapaʻau i kuhikuhi nui ʻia no ka mālama ʻana i ka maʻi maʻi umauma.ʻO ka mea maʻamau i kapa ʻia ʻo Selective Estrogen Receptor Modulator (SERM), ua hoʻohana mua ʻia no ka pale ʻana i ka gynocomastia.
Ka hana o Exemestane
A)Exemestane no ka pale ʻana i ka maʻi kanesa o ka umauma:
ʻO ka Chemoprevention o ka maʻi kanesa o ka umauma kahi hoʻolālā kūpono e hōʻemi i ka ulu ʻana o kēia maʻi i nā wahine i ka pilikia.ʻO nā mea hana mua i hōʻike i kahi hopena chemopreventive koʻikoʻi ka SERMs tamoxifen a me raloxifen.
Ua hōʻike ʻia kahi hōʻuluʻulu piha ʻana o nā hoʻāʻo pale SERM āpau i hiki iā lākou ke hōʻemi i ka ulu ʻana o ka maʻi kanesa o ka umauma i nā wahine kiʻekiʻe a me ka awelika-pilikia, kahi hopena i hoʻomau ʻia e ka emi ʻana o ka maʻi maʻi umauma invasive ER-positive.
B)ʻO Exemestane he kolu o ka hanauna hikiʻole ke hoʻololi i ka steroidal inactivator o ka enzyme aromatase a he kūpono ia i nā hoʻonohonoho mālama āpau no ka maʻi kanesa o ka umauma, me ka chemoprevention.
I ka hoʻonohonoho metastatic, ua noiʻi nui ʻia ka exemestane ma ke ʻano he lālani mua, laina ʻelua, a me ka lāʻau lapaʻau hou aʻe a ua hoʻopaʻa inoa ʻia no ka mālama ʻana i nā wahine postmenopausal me ka maʻi maʻi umauma hormone-receptor-positive i holomua ka maʻi ma hope o ka antiestrogen. lāʻau lapaʻau.
ʻO ka ʻike, ʻo ka nele o ka cross-resistance me NSAIs e hāʻawi i nā manawa hou i ka papa hana o nā mea hana endocrine.Eia kekahi, ma muli o nā hopena koʻikoʻi o ka maʻi, ʻo exemestane me everolimus kahi koho therapeutic kūpono no kahi maʻi i holomua ma hope o ka ʻike ʻana i nā NSAI.
Hoʻomaʻamaʻa maikaʻi ʻia ʻo Exemestane, me kahi ʻaoʻao ʻaoʻao e like me nā AI ʻē aʻe a me nā hōʻailona menopausal, arthralgia, nalo iwi, a me ka hoʻololi ʻana i ka metabolism lipid.
